Medicine
Volume 35, Issue 12 , Page 623, December 2007

Hydrogen sulphide

Allister Vale MD FRCP FRCPE FRCPG FFOM FAACT FBTS is Director of the National Poisons Information Service (Birmingham Unit) and the West Midlands Poisons Unit at City Hospital, Birmingham, UK. Competing interests: none declared

Abstract 

Hydrogen sulphide is a potent inhibitor of cytochrome oxidase A3 and a mucous membrane irritant at lower concentrations. Cyanosis, confusion, pulmonary oedema, coma, convulsions and respiratory arrest are common in severe poisoning and neurological and neuropsychiatric sequelae have been observed. Rescue, resuscitation if necessary, and the administration of oxygen are the mainstay of treatment.

Keywords: cytochrome oxidase A3 inhibitor, neuropsychiatric sequelae, pulmonary oedema, sodium nitrite, subacute encephalopathy

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PII: S1357-3039(07)00312-X

doi:10.1016/j.mpmed.2007.09.001

Medicine
Volume 35, Issue 12 , Page 623, December 2007

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