Medicine
Volume 35, Issue 12 , Page 631, December 2007

LSD

Allister Vale MD FRCP FRCPE FRCPG FFOM FAACT FBTS is Director of the National Poisons Information Service (Birmingham Unit) and the West Midlands Poisons Unit at City Hospital, Birmingham, UK. Competing interests: none declared

Abstract 

Lysergic acid diethylamide (LSD) acts as an antagonist at peripheral 5-HT receptor subtypes, but as a 5-HT2A receptor agonist in the CNS. In severe poisoning, hyperreflexia, tremor, muscle twitching, coma, seizures, hypotension and respiratory arrest have been reported. In addition, changes in perception, mood and behaviour, panic, agitation and excitement, visual hallucinations, delusions and psychosis are observed. Hallucinogen persisting perception disorder (‘flashbacks’) may persist for several years after exposure has ceased.

Keywords: ‘flashbacks’, hallucinogen, hallucinogen persisting perception disorder, LSD

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PII: S1357-3039(07)00320-9

doi:10.1016/j.mpmed.2007.09.010

Medicine
Volume 35, Issue 12 , Page 631, December 2007

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