Medicine
Volume 36, Issue 1 , Pages 19-23, January 2008

Principles of cytotoxic chemotherapy

M J Lind BSc MD FRCP is Foundation Professor of Oncology at the University of Hull and Honorary Consultant Oncologist at the Hull and East Yorkshire NHS Trust, Hull, UK. He qualified from and trained in oncology at Guy's Hospital, London. His major interests are breast and lung cancer, and the pharmacology of anti-cancer drugs. Competing interests: none declared

Abstract 

Chemotherapy with cytotoxic anticancer agents remains the mainstay of therapy targeted at specific cellular mechanisms in malignant disease. Increasingly it is being used earlier on in a patient’s treatment as an adjunct to either surgery or radiotherapy. Newer molecularly targeted agents are beginning to show great promise in some disease, such as gastrointestinal stromal tumours and chronic myeloid leukaemia.

Keywords: alkylating agents, anthracyclines, antimetabolites, cancer, chemotherapy, cytotoxic, platinum compounds, tumours

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PII: S1357-3039(07)00344-1

doi:10.1016/j.mpmed.2007.10.003

Medicine
Volume 36, Issue 1 , Pages 19-23, January 2008

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