Medicine
Volume 36, Issue 7 , Pages 355-359, July 2008

Drug metabolism

Munir Pirmohamed MBChB PhD FRCPE FRCP holds the NHS Chair in Pharmacogenetics, and is Professor of Clinical Pharmacology and Honorary Consultant Physician at the University of Liverpool, UK. His research interest is optimization of drug therapy through characterization of environmental and genetic factors that lead to inter-individual variability in the pharmacokinetic and pharmacodynamic aspects of drug therapy. Competing interests: none declared

Abstract 

Drug metabolism is a clinically important process occurring throughout the body, but principally in the liver, which determines the efficacy and toxicity of many of the most widely used drugs. Knowledge of drug metabolism is important in optimizing the use of drugs, maximizing benefits and minimizing harms.

Keywords: bioactivation, cytochrome P450 enzymes, enzyme induction, enzyme inhibition, genetic polymorphisms, interactions, metabolism

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PII: S1357-3039(08)00111-4

doi:10.1016/j.mpmed.2008.04.002

Medicine
Volume 36, Issue 7 , Pages 355-359, July 2008

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